In biohacking and cognitive enhancement, there is a growing search for chemicals that can enhance mental function and reduce the release of stress hormones. In this field, the peptides Semax and Selanc have received great interest.
Semax and Selank peptides are short chains of amino acids that are synthesized in the laboratory. Studies suggest that these bioactive chemicals discovered in Russia may have the ability to reduce stress hormone release as well as improve memory and attention.
Research shows that Semax has established a niche among licensed professionals interested in potentially enhancing cognitive skills despite its original development for a variety of neurological problems. However, investigation suggests that Selenk may provide an attractive option for scientists wishing to study potential relief from stress in animal research models.
In this essay, we will compare and contrast Semax and Selenc from a scientific and practical perspective so you can decide which one is best for your research.
What is Semax Peptide?
Semax is a synthetic peptide originally developed to mimic the effects of adrenocorticotropic hormone (ACTH). This bioactive molecule, manufactured in Russia, is a series of seven amino acids believed to be essential for peak cognitive performance.
Studies show that increased levels of brain-derived neurotrophic factor (BDNF) are important for Semax’s mechanism of action. Increased levels of BDNF contribute to improved synaptic plasticity, memory formation, and overall cognitive performance. Thus, the researchers speculate that Semax could be used in a variety of cognitive research applications, such as studies enhancing memory, focus, and problem-solving skills.
Beyond its use in cognitive improvement, Semax has shown potential in the context of neurological diseases including stroke effects, Alzheimer’s disease and attention deficit hyperactivity disorder (ADHD).
What is Selank Peptide?
The synthetic peptide Selank has attracted much attention for its potential role in reducing stress hormone release. Selank, a sequence of seven amino acids manufactured in Russia as a nootropic and anxiolytic, is produced in the country. Research suggests that its main purpose is to manage the organism’s response to stress by regulating the secretion of stress hormones, including cortisol.
It is proposed that Selank may exert its potential by modulating neurotransmitter systems, namely serotonin, which is important for preserving a stable emotional state. Investigations show that by increasing levels of the neurotransmitter serotonin, Selank may potentially reduce the negative long-term effects of exposure to stress hormones.
Semax Peptide: How does it work?
The use of Semax peptide has suggested great potential as a means of improving cognition and protecting nerve cells. Research shows that not only does it appear to behave like BDNF (brain-derived neurotrophic factor), but this is just one of several possible routes of its action.
By modulating the expression of genes involved in immune cell number and motility, Semax is hypothesized to exert substantial control over the immunological response. As a result, production of immune system proteins, chemokines, and immunoglobulins may increase.
Furthermore, Semax has been predicted to affect the expression of genes important for the formation and function of the vascular system in rat brain localized ischemia. This combined effect on the immune and cardiovascular systems appears to be the key to the neuroprotective potential of Semax. In addition to promoting new nerve cell growth and flexibility, it may help the brain recover more quickly from ischemic injuries.
Selank Peptide: How does it work?
Researchers interested in studies on cortisol release and other stress hormone explorations may consider Selank as a potential research compound for further investigation. Licensed professionals interested in studying the potential of this compound can do so by purchasing from Core Peptides.
Serotonin, a neurotransmitter that has important functions in mood regulation, has been proposed as the primary target of action of Selank. It has been hypothesized that celandine’s ability to increase serotonin levels may potentially reduce symptoms of anxiety and depression, which in turn supports hormonal stability.
Additionally, new studies have shown that Selank may have antiviral effects due to its proposed mechanism of action. The results suggest that it can directly and indirectly affect the balance of Th1/Th2/Treg cytokines through the central nervous system. This modification is believed to enhance its ability to boost the immune response against viral infection.
Studies show that both memory and concentration can potentially be improved with the help of Semax peptide, although the perception of stress and mood swings can be reduced with Semax.
It is anticipated that both peptides may be promising, but researchers should proceed with caution while following all applicable regulations. Please note that none of the substances mentioned in this article are approved for human consumption, and this paper is for educational purposes only.
(i) National Center for Biotechnology Information (2023). PubChem compound summary for CID 9811102, Semax. Retrieved November 13, 2023, from https://pubchem.ncbi.nlm.nih.gov/compound/Semax.
(ii) National Center for Biotechnology Information (2023). PubChem compound summary for Selank. Retrieved November 13, 2023, from https://pubchem.ncbi.nlm.nih.gov/compound/Selank.
(iii) Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV. Peptide Semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014 Mar 24;15:228. doi:10.1186/1471-2164-15-228. PMID: 24661604; PMCID: PMC3987924.
(iv) Ershov FI, Uchakin PN, Uchakina ON, Mezentseva MV, Alekseeva LA, Miasoedov NF. (Antiviral activity of the immunomodulator Selank in experimental influenza infection). Vopr Virusol. 2009 Sep-Oct;54(5):19-24. Russian. PMID: 19882898.
(v) Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV. Peptide Semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014 Mar 24;15:228. doi:10.1186/1471-2164-15-228. PMID: 24661604; PMCID: PMC3987924.
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